Using PuraStat® Haemostatic Solution in ENT Endonasal Surgery

InterMed is proud to partner with 3-D Matrix Medical Technology to bring PuraStat®, an innovative haemostatic solution to healthcare professionals across New Zealand.

Why use PuraStat® in ENT Endonasal Surgery?

Managing bleeding in endonasal surgery is a critical challenge due to the highly vascular nature of nasal tissue. Traditionally, tamponade with nasal packing has been used to achieve haemostasis, but this can compromise patient comfort and potentially affect delicate surgical outcomes.

PuraStat® offers a modern, patient-focused alternative. Designed for precise haemostasis without excessive pressure, it provides ENT surgeons with greater control during procedures¹ ³ while improving the post-operative experience for patients.

PuraStat® Advantages

Synthetic Peptide

• Inert material — no risk of contamination.

Ease of Use

• Supplied as a single prefilled, ready-to-use syringe.
• No preparation required.
• Suitable for endoscopic surgery.
• Allows suturing or cauterisation if required.

Transparent Haemostat

• Maintains clear visibility of the bleeding point.

Re-Applicable & Removable

• Can be reapplied multiple times during the same procedure.
• Easily removed if desired.

Slightly Viscous Solution

• Ideal for endoscopic use.
• Applies effectively in narrow spaces.
• Covers uneven surfaces with ease.

PuraStat® Mode of Action

PuraStat® is a slightly viscous solution of synthetic peptides. When PuraStat® comes into contact with blood, the acidic peptide solution is neutralised and exposed to ions. This reaction triggers the formation of ß-sheets, which self-assemble into a 3-dimensional scaffold structure.

This scaffold provides a physical barrier, stopping bleeding effectively across a wide range of surgical indications² ⁴ — from ENT endonasal surgery to open, laparoscopic, and endoscopic procedures.

▶ Watch the PuraStat® Mode of Action video – RADA16

Explore PuraStat® in New Zealand

PuraStat® is available exclusively in New Zealand through InterMed’s Surgical team. We invite healthcare professionals to explore the advantages of this innovative haemostatic solution for ENT and beyond.

Frequently Asked Questions

Q: What makes PuraStat® different from other haemostats?

A: PuraStat® is a synthetic peptide solution (2.5% RADA16), transparent in nature, which supports precise application and visibility during surgery.

Q: Can PuraStat® be reapplied?

A: Yes, it can be applied multiple times within the same procedure if needed.

Q: Is PuraStat® limited to ENT use?

A: No, PuraStat® is used across multiple surgical specialties, including open, laparoscopic, and endoscopic procedures.

References

1. Nishiguchi M, et al. A self-assembling peptide haemostatic agent for endoscopic sinus surgery: a clinical evaluation. J Laryngol Otol. 2016;130(S2):S90–S96.
2. Sankar S, O’Neill J, Bagot d’Arc M. Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine. Front Bioeng Biotechnol. 2021;9:679525. Available at: https://www.frontiersin.org/articles/10.3389/fbioe.2021.679525/full
3. RADA16, a Self-Assembling Peptide (SAP) for Haemostasis in Nasal Endoscopic Surgery: A Case Series in Australia. Surg Case Studies J. 2022. Available at: https://lupinepublishers.com/surgery-case-studies-journal/fulltext/rada16-a-self-assembling-peptide-sap-for-haemostasis-in-nasal-endoscopic-surgery-a-case-series-in-australia.ID.000247.php
4. Yamakawa K, et al. Clinical experience with a novel self-assembling peptide haemostatic material in cardiovascular surgery. Surg Today. 2015;45(7):819–826.

DISCLAIMER:

Some of the products mentioned in this blog are intended for use by healthcare professionals only.

ALWAYS READ THE LABEL AND FOLLOW THE DIRECTIONS FOR USE